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FOSPHENYTOIN PRESCRIBING INFORMATION PDF

This resource may include information that has not been approved by the US Food and Drug Administration. For full prescribing information, including. Fosphenytoin official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Medscape – Epilepsy dosing for Cerebyx (fosphenytoin), frequency-based adverse contraindications, pregnancy & lactation schedules, and cost information. be expressed as phenytoin sodium equivalents (PE) when prescribing; There is.

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This occurs within approximately 2 hours after the end of IV infusion and 4 hours after intramuscular IM injection. This site uses cookies. These sensations, generally described as itching, burning, or tingling, were usually not at the infusion site. The risk of hepatotoxicity and other hypersensitivity reactions to phenytoin may be higher in black patients. Ethanol Fosphenytoin may increase the central nervous system depressant CNS depressant activities of Ethanol.

The following drug interactions are the most commonly occurring drug interactions with phenytoin:. Methysergide The metabolism of Methysergide can be increased when combined with Fosphenytoin. Patient age had no significant impact on fosphenytoin pharmacokinetics.

Dihydroergotamine The metabolism of Dihydroergotamine can be increased when combined with Fosphenytoin.

Fosphenytoin

Gantacurium Chloride The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Gantacurium Chloride. Genetic toxicity studies showed that fosphenytoin was not mutagenic in bacteria or in mammalian cells in vitro. Following CEREBYX administration, it is recommended that phenytoin concentrations not be monitored until conversion to phenytoin is essentially complete. Fosphenytoin can cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson Syndrome SJSand toxic epidermal necrolysis TENwhich can be fatal.

Amitriptylinoxide The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Amitriptylinoxide. Cerivastatin The metabolism of Fosphenytoin can be increased when combined with Cerivastatin.

Fosphenytoin – FDA prescribing information, side effects and uses

Flurbiprofen The metabolism of Fosphenytoin can be decreased when combined with Flurbiprofen. Fluprednidene The metabolism of Fosphenytoin can be decreased when combined with Fluprednidene. Lacidipine The metabolism of Fosphenytoin can be decreased when combined with Lacidipine.

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Prescrobing The metabolism of Fosphenytoin can be increased when combined with Corticotropin. Lysergic acid diethylamide The metabolism of Fosphenytoin can be decreased when combined with Lysergic acid diethylamide. Subscribe to free Drugs.

The liver is the site of biotransformation. Ketanserin The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Ketanserin. Metharbital The risk or severity of adverse effects can be increased when Metharbital is combined with Fosphenytoin.

Patients should be monitored closely for more rapid recovery from neuromuscular blockade than expected, and infusion rate requirements may be higher. Corticosterone The metabolism of Fosphenytoin can be decreased when combined with Corticosterone. Genistein The metabolism of Fosphenytoin can be increased when combined with Genistein. Fluspirilene The metabolism of Fosphenytoin can be decreased when combined with Fluspirilene.

One mL of Pro-Epanutin contains 75 mg of fosphenytoin sodium equivalent to 50 mg of phenytoin sodium see section 4. Evening primrose oil The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with Evening primrose oil.

Phenytoin when given with the combination of fosamprenavir and ritonavir may increase the concentration of amprenavir. Fosphenytoin is completely bioavailable following IM administration of Fosphenytoin Sodium Injection. In some cases, milder sensory disturbances persisted for as long as 24 hours. Celecoxib The metabolism of Fosphenytoin can be decreased when combined with Celecoxib.

fospgenytoin Inform patients that rapid intravenous administration of CEREBYX increases informafion risk of adverse cardiovascular reactions, including severe hypotension and cardiac arrhythmias. Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Fosphenytoin. Dextropropoxyphene The metabolism of Fosphenytoin can be decreased when combined with Dextropropoxyphene.

After the initial maintenance dose, subsequent maintenance doses should be individualized by monitoring serum phenytoin concentrations to achieve a target therapeutic concentration of phenytoin [see Dosage and Administration 2. Mepartricin The metabolism of Fosphenytoin can be decreased when combined with Mepartricin. Eltrombopag The metabolism of Fosphenytoin can be decreased when combined with Eltrombopag.

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Golimumab The metabolism of Fosphenytoin can be increased when combined with Golimumab. Following administration of oral phenytoin, phenytoin appears to be excreted in fosphemytoin concentrations in human milk.

The error is dependent on serum phenytoin and fosphenytoin concentration influenced by CEREBYX dose, route and rate of administration, and time of sampling relative to dosingand analytical method.

Fosphenytoin – DrugBank

The adverse events most commonly associated with withdrawal were pruritus 0. Ivosidenib The metabolism of Fosphenytoin can be increased when combined with Ivosidenib.

Care should be taken to ensure the appropriate volume of Pro-Epanutin is withdrawn from the vial when preparing the drug for administration. The adverse reactions most commonly observed with the use of CEREBYX in clinical trials were nystagmus, dizziness, pruritus, somnolence, and ataxia. Advise women of childbearing potential who are not planning a pregnancy to use effective contraception while using Fosphenytoin Sodium Injection, keeping in mind that there is a potential for decreased hormonal contraceptive efficacy [see Drug Interactions 7.

The hydrolysis of Fosphenytoin to phenytoin yields two metabolites, phosphate and formaldehyde. Instruct patients to notify their physician if they become pregnant or intend to become pregnant during therapy, and to notify their physician if they are breastfeeding or intend to breastfeed during therapy [see Use in Specific Populations 8.

Estradiol dienanthate The metabolism of Fosphenytoin can be increased when combined with Estradiol dienanthate.

Desmethylsertraline The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with Desmethylsertraline.